Trifluoromethyl: Webster's Timeline History, 1950 - 2007
Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Trifluoromethyl," including when used in literature (e.g. all authors that might have Trifluoromethyl in their name). As such, this book represents the largest compilation of timeline events associated with Trifluoromethyl when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social sciences (linguistics, history, geography, economics, sociology, political science), business, computer science, literature, law, medicine, psychology, mathematics, chemistry, physics, biology and other physical sciences. This "data dump" results in a comprehensive set of entries for a bibliographic and/or event-based timeline on the proper name Trifluoromethyl, since editorial decisions to include or exclude events is purely a linguistic process. The resulting entries are used under license or with permission, used under "fair use" conditions, used in agreement with the original authors, or are in the public domain.
Chemistry of a, a - Unsaturated Trifluoromethyl Ketones
This book addresses the fact that the trifluoromethyl group, due to its unique stereoelectronic properties, as a very important substituent in medicinal chemistry. The trifluoromethyl group usually increases lipophilisity of the molecules improving their transport characteristics in vivo. Furthermore, the durability of C-F bond comparing with N-I bond (116 and 100 kcal/mol correspondingly) allows to avoid undesirable metabolic transformations. The introduction of trifluoromethyl group into bioactive molecules becomes very important direction in pharmaceutical studies that stimulates the works directed to elaboration of synthetic methodology for various compounds containing trifluoromethyl group. Due to all these factors organofluorine chemistry has been vigorously developing during the last two decades.
